Sporadic Alzheimer's disease (AD) is an emerging chronic illness characterized by a progressive pleiotropic pathophysiological mode of actions triggered during...
Optical imaging offers high sensitivity and portability at low cost. The design of an optimal "activatable" imaging agent could greatly decrease the background...
Journal of Nanoscience and Nanotechnology, 2014, Volume : 14, Numéro : 7
Diagnosis of glioblastoma multiform (GBM) with MRI lacks molecular information and requires a biopsy for pathologic confirmation. The EGFRvIII, is a...
A mouse model of glioblastoma multiforme was used to determine the accumulation of a targeted contrast agent in tumor vessels. The contrast agent, consisting...
Methods in molecular biology (Clifton, 2011, Volume : 686
The development of imaging and therapeutic agents against neuronal targets is hampered by the limited access of probes into the central nervous system across...
European Journal of Cancer Supplements, octobre 2008
In situ brain perfusion were used to assess the brain uptake of our conjugates. Analysis of tissues was done after extraction by LC-MS-MS or HPLC. Xenograft...
British Journal of Cancer, 9 septembre 2010, Volume : 103, Numéro : 10
BACKGROUND: Insulin-like growth factor-binding protein 7 (IGFBP7) is an abundant, selective and accessible biomarker of glioblastoma multiforme (GBM) tumour...
Noninvasive investigation of cellular and molecular processes becomes possible through the novel techniques, one of which is molecular imaging, where enhanced...
British Journal of Cancer, 22 novembre 2011, Volume : 105, Numéro : 11
ANG1005 consists of three molecules of paclitaxel conjugated via ester bonds to the 19-amino-acid peptide Angiopep-2. The new chemical agent has been shown to...
British Journal of Pharmacology, 2010, Volume : 160, Numéro : 4
Background and purpose: The overexpression of epidermal growth factor receptor (EGFR) and its mutated variant EGFRvIII occurs in 50% of glioblastoma...
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