We continued prospective assessments of the Wilma-solvated interaction energy (SIE) platform for pose prediction, binding affinity prediction, and virtual...
Current Pharmaceutical Design, 2014, Volume : 20, Numéro : 20
Water plays an active role in many fundamental phenomena in cellular systems such as molecular recognition, folding and conformational equilibria, reaction...
European Journal of Cancer, décembre 2016, Volume : 69
In efficacy studies using the syngeneic 4T1 TNBC model, AVID200 was shown to promote significant T-cell infiltration into tumors. This infiltration resulted in...
New Therapies, BMJ Publishing Group Ltd, 30 juin 2018, Volume : Suppl. 2
Introduction Poor vascularisation of solid tumours leads to inadequate nutrient and oxygen supplies which forces tumour cells to reprogram their metabolism. As...
Processing of prohormones to generate active products typically occurs at basic residues via cleavage by proprotein convertases. A less common type of cleavage...